Choose a disease that affect or impact the peripheral nervous system and its potential treatment for that disease.

In a short word,Choose a disease that affect or impact the peripheral nervous system and its potential treatment for that disease.

Introduction

Peripheral nervous system (PNS) injuries are a common disorder that may cause severe chronic pain and disability. The peripheral nervous system (PNS) has the ability for regeneration for most of injuries due to its plasticity. However, the regeneration capacity could be weakened by the tissue damage of a peripheral nerve. For example, a crush or transection injury to PNS can be repaired by reconnecting the peripheral nerve, but poor regeneration may occur after an injury of mixed severity (not only crush or transection). In this case, there is no obvious neural discontinuity that could be simply repaired by connecting cut ends of the nerve. Even if microsurgical repair with end-to-end neurorrhaphy is performed in this case, poor regeneration will still lead to limb function loss. Thus, we have to offer new ideas and methods to promote peripheral nerve regeneration in order to improve clinical outcomes after peripheral nerve injury

Peripheral nerve injury is a common disorder, which may cause severe chronic pain and disability. The peripheral nervous system (PNS) has the ability for regeneration for most of injuries due to its plasticity. However, the regeneration capacity could be weakened by the tissue damage of a peripheral nerve. For example, a crush or transection injury to PNS can be repaired by reconnecting the peripheral nerve, but poor regeneration may occur after an injury of mixed severity (not only crush or transection). In this case, there is no obvious neural discontinuity that could be simply repaired by connecting cut ends of the nerve. Even if microsurgical repair with end-to-end neurorrhaphy is performed in this case, poor regeneration will still lead to limb function loss. Thus, we have to offer new ideas and methods to promote peripheral nerve regeneration in order to improve clinical outcomes after peripheral nerve injury.

Conclusion

So far, the literature has suggested that the use of stem cells may be able to promote peripheral nerve regeneration. However, more studies are needed to validate this hypothesis and its clinical applications in real life.